Composite Hydrogel Preparation and Physico Chemical Characterization from Silk Fibroin

Abstract

Hydrogels are effective in wound healing and other tissue engineering applications. In our study hydrogel was prepared using Silk fibroin, Chitosan and Gelatin. A simple mixing of chitosan, gelatin and silk fibroin solutions was done to get a new composite silk fibroin based hydrogel (SFH) type. The hydrogels based on silk fibroin, chitosan and gelatin provide a moist wound environment which intern accelerate the process of wound healing and tissue regeneration. The applications silk proteins in biomedical products has been increased due to their mechanical properties and biocompatibility. The effectiveness of wound healing process was increased when using chitosan- based hydrogels or other combinations of hydrogels. Further characterization of silk based hydrogel is done using various tests to check the swell ability, biodegradability and biocompatibility of silk hydrogel. The results show that silk based hydrogel play a promising role in wound healing