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We investigated the structural and functional features of immunocompetent breast cells in the dynamics of pregnancy and lactation and against the background of chronic hepatitis. The work was carried out on sexually mature female white outbred rats, the right inguinal mammary glands of non-pregnant women were examined on days 5, 14, 17, 21 of pregnancy and on days 1, 3, 7, 15, and 21 after birth in normal conditions and chronic gelnotrine hepatitis. The samples were examined using morphological and electron microscopic research methods. It was found that in the dynamics of pregnancy and lactation, there is a gradual infiltration of the perialveolar connective tissue and terminal secretory sections of the mammary gland by immunocompetent cells, reaching their peak on the 3rd day of lactation. In immunocompetent cells of the mammary gland, ultrastructural changes occur, associated with certain relationships with epithelial cells, which determine the transfer of adoptive immunity to the newborn. In experimental chronic hepatitis in late pregnancy and in the dynamics of lactation, a decrease in the infiltration of the mammary gland by immunocompetent cells, an increase in the content of heterophagosomes of macrophages and lysosomes in lymphocytes, indicating violations of the immuno-epithelial relationships in the mammary gland, was established.
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