Impact of Depression on Health-Related Quality of Life among Patients with Functional and Gastrointestinal Motility Disorders

Abstract

Psychological factors exert an influence on the expression of functional and gastrointestinal motility symptoms. This study aims to examine the prevalence of depression, health-related quality of life of patients with functional and gastrointestinal motility disorder, and to examine the correlation between depressive symptoms and self-rated health status and utility index. The 175 participants recruited from a motility clinic completed Patient Health Questionnaire – 9 (PHQ-9), 5-level EQ-5D version (EQ-5D-5L), and Short Form (36) Health Survey. Data were analyzed by descriptive statistic and analysis of correlation. Approximately 25% had depression. Quality of life scores were 76.01 + 13.45 by EQ-5D-5L and 59.28 + 20.87 (physical components) and 66.10 + 19.12 (mental components) by Short Form (36) Health Survey. The depressive score was significantly correlated with self-rated health status (r = -0.428, p < 0.001) and utility index (r = -0.350, p < 0.001) of quality of life. In conclusion, depression is prevalent among patients with functional and gastrointestinal motility disorders. Clinicians and psychologists should evaluate their mood symptoms during follow-up their physical symptoms for improvement of health-related quality of life.