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Psychological factors exert an influence on the expression of functional and gastrointestinal motility symptoms. This study aims to examine the prevalence of depression, health-related quality of life of patients with functional and gastrointestinal motility disorder, and to examine the correlation between depressive symptoms and self-rated health status and utility index. The 175 participants recruited from a motility clinic completed Patient Health Questionnaire – 9 (PHQ-9), 5-level EQ-5D version (EQ-5D-5L), and Short Form (36) Health Survey. Data were analyzed by descriptive statistic and analysis of correlation. Approximately 25% had depression. Quality of life scores were 76.01 + 13.45 by EQ-5D-5L and 59.28 + 20.87 (physical components) and 66.10 + 19.12 (mental components) by Short Form (36) Health Survey. The depressive score was significantly correlated with self-rated health status (r = -0.428, p < 0.001) and utility index (r = -0.350, p < 0.001) of quality of life. In conclusion, depression is prevalent among patients with functional and gastrointestinal motility disorders. Clinicians and psychologists should evaluate their mood symptoms during follow-up their physical symptoms for improvement of health-related quality of life.
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