Synthesis of Pyrazolopyrimidine Derivatives and Its Antioxidants Activity

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S. Singh, Dr. Mohammad Gousuddin

Abstract

The process of new drug development requires a great deal of time and resources. The theoretical studies have a fundamental role to minimize these factors because they show indications of potential drug applications. Several authors mention that it is not enough for a compound to present high biological activity and low toxicity to be tested as a drug; it is also necessary to meet the ADME pharmacokinetics parameters (absorption, distribution, metabolism and excretion), which determine the access and the concentration of the compound in the therapeutic target and its subsequent elimination by the organism. Many drug candidates can be discarded for presenting unfavorable pharmacokinetics. The ADME parameters can be verified by in silico studies based on calculated physico-chemical standards. These standards emphasize lipophilicity, water solubility, molecule size and flexibility.

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