Histological Study for Some Organ of Albino Mice Exposed to Heavy metals Copper Sulphate and Lead Nitrate

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Abeer Cheaid Yousif Al-Fatlawi, Muntdhur Mohammad cani


The present study was carried out the histological changes induced by lead nitrate [Pb (NO3)2] and Copper Sulphate (CuSO4.5H2O) toxicity in 48 mature Albino Mice were divided into 7 groups each with 5 mice. Group 1 served as control received tap water, group 2, 3, 4 received (2,4,6 mg /kg of body weight) from lead nitrate, while group 5, 6, 7 received (50,100,150 mg /kg of body weight) from Copper Sulphate respectively in drinking water for 6 weeks. After end of treatment with heavy metals the mice were sacrificed. The lesions were characterized by degeneration, necrosis, and fibrosis, cellular and vascular changes in the heart, lung and spleen. The intensity and distribution of such lesions found more severe in mice treated with highest dose from both elements.

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