Pathological and hormonal effects of 2,3,7,8- Tetrachlorodibenzo-P-Dioxin ( TCDD ) versus antioxidant activity of Curcumin In Sprague Dawley Male Rats

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Anas A. Humadi, Bushra I. Al-Kaisei, Marah S. Hameed


Current experiment was designed to evaluate the chronic effects of 2,3,7,8- Tetrachlorodibenzo-p-dioxin ( TCDD ) intoxicant effects and Curcumin antioxidant effects on pathological and hormonal assay in Sprague Dawley male rats at day 90. Thirty male rats divided randomly and equally into 3 groups, control group ( negative control ) received only normal pellet and corn oil, 2nd group ( positive group ) act as TCDD group received orally weekly for 90 day by stomach tube ( 2 µg / kg ), while 3rd group received weekly by stomach tube ( 2  µg / kg ) TCDD with ( 100 mg / kg ) daily Curcumin for 90 day. Testosterone hormone and sperm analysis ( viability, number and abnormality ) assay significantly decrease (P<0.05) at 2nd group when compare with control and 3rd group , while pathological changes indicated at 2nd group testicular carcinoma characterized by pleomorphic and polyhydral of leydig cells and sertoli cells.

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