Pathological and hormonal  effects of   2,3,7,8- Tetrachlorodibenzo-P-Dioxin ( TCDD ) versus  antioxidant  activity of Curcumin In Sprague Dawley Male Rats

Anas A. Humadi, Bushra I. Al-Kaisei,  Marah S. Hameed

doi:10.17762/pae.v58i2.3206

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Published: Feb 20, 2021

DOI: https://doi.org/10.17762/pae.v58i2.3206

Anas A. Humadi, Bushra I. Al-Kaisei, Marah S. Hameed

Abstract

Current experiment was designed to evaluate the chronic effects of 2,3,7,8- Tetrachlorodibenzo-p-dioxin ( TCDD ) intoxicant effects and Curcumin antioxidant effects on pathological and hormonal assay in Sprague Dawley male rats at day 90. Thirty male rats divided randomly and equally into 3 groups, control group ( negative control ) received only normal pellet and corn oil, 2^nd group ( positive group ) act as TCDD group received orally weekly for 90 day by stomach tube ( 2 µg / kg ), while 3^rd group received weekly by stomach tube ( 2 µg / kg ) TCDD with ( 100 mg / kg ) daily Curcumin for 90 day. Testosterone hormone and sperm analysis ( viability, number and abnormality ) assay significantly decrease (P<0.05) at 2^nd group when compare with control and 3^rd group , while pathological changes indicated at 2^nd group testicular carcinoma characterized by pleomorphic and polyhydral of leydig cells and sertoli cells.

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Vol. 58 No. 2 (2021): Volume 58 No. 2 (2021)

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