LEVELS OF SERUM URIC ACID IN PATIENTS WITH IMPAIRED GLUCOSE TOLERANCE

Abstract

Objective: The main objective of this study is to see levels of serum uric acid in patients
having impaired glucose tolerance as compared to normal glucose tolerant individuals.
Patients and Methods: This was prospective study, conducted at Department of Medicine
and Department of Pathology, Indus Medical College Hospital, Tando Muhammad Khan
for the period of 8 months (March 2019 to October 2019). A total of 140 patients were
included in this study. An oral glucose test was performed with load of 75g glucose in
patients having impaired glucose in fasting. Both normal glucose tolerance and impaired
glucose tolerance individuals were evaluated for their serum uric acid level. Serum glucose
levels and serum uric acid levels were performed on COBAS C-111 Chemistry Analyzer
ensuring procedures of quality control. Data was entered and analyzed using SPSS 21.0.
Results: In patients having impaired glucose tolerance, the frequency of hyperuricemia
was 62.35%. Analysis of both groups (patients with normal glucose tolerance and glucose
intolerance), association was strong with p-value of <0.001.
Conclusion: Majority of patients with impaired glucose tolerance showed hyperuricemia
as compared to individuals with normal glucose tolerance. Hyperuricemia should be kept in
routine investigation in patients with impaired glucose tolerance as it can reduce the risk of
secondary complications of hyperuricemia in patients with pre-diabetes.